A biopsy is the removal of a tissue sample from the body for histological or microscopic examination; therefore only very small samples are usually needed. During examination of the large intestine and the stomach, a biopsy will be taken with forceps through the endoscope.
This is not painful at all.
A stomach biopsy involves removing a sample of the lower and upper part of the stomach as well as from the oesophagus and duodenum in some occasion if we see suspicious area. This will identify if a bacterial contamination is present. This is absolutely painless and does not require local anaesthesia.
A breast biopsy involves removing a sample of breast tissue to determine whether it is cancerous or benign (non-cancerous). While physical breast exam, mammography, ultrasound, and other breast imaging methods can help detect a breast abnormality, a biopsy followed by microscopic analysis is the only definitive way to determine what kind of tumour is present. Once the radiologist or surgeon has removed a sample of breast tissue, a pathologist sends it to the laboratory for microscopic examination. A clinical pathologist is a special physician who performs laboratory analyses of tissues to determine their type.
This is performed under local anaesthesia and is generally not painful. If the tumour cannot be felt, a stereotactic (x-Ray) radiologic sampling is indicated.
When there are changes in the skin that require further examination, a skin biopsy may be useful. First, a local anaesthetic is given, and then a small piece of skin is cut off with a scalpel. Then the skin is sewn together again with a couple of stitches or Steri-Strips. This may leave a very small, visible scar.